期刊
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
卷 24, 期 8, 页码 1161-1164出版社
WILEY
DOI: 10.1002/rcm.4497
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-
资金
- Spanish Ministry of Education and Science [AGL2004-08215-CO3-02]
Mechanisms of retinol (ROL) transport in plasma alternative to that involving the Retinol-Binding Protein (RBP) have been hypothesized after RBP-knockout mice were shown to be viable and fertile. Accordingly, the possibility of a ROL fraction circulating free in plasma has been suggested. In this study, stable complex formation between ROL and the physiological relevant ions Na+, Li+, and K+ was investigated by using mass spectrometry and assessed in regard to the aforementioned alternative mechanism. The ROL-Na complex was found to be kinetically favoured with respect to the ROL-Li and ROL-K complexes. Fragmentation of the [ROL-Na](+) adduct rendered the carbocation [ROL+H-H2O](+) (m/z 269) and NaOH as neutral loss. In consonance with these results, it is hypothesized on the possibility of the complex [ROL-Na](+) being an alternative way of ROL transport to cells, as well as an intermediate in cis/trans isomerism. Copyright (C) 2010 John Wiley & Sons, Ltd.
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