期刊
RADIOTHERAPY AND ONCOLOGY
卷 110, 期 2, 页码 342-347出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2013.12.013
关键词
Gold nanoparticles; Radiosensitisers; Toxicity; Hypoxia
资金
- Men Against Cancer
- Cancer Research UK [C1278/A990, C1513/A7047]
- EPSRC [EP/K039342/1] Funding Source: UKRI
- MRC [G0502183] Funding Source: UKRI
- STFC [ST/K001957/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K039342/1] Funding Source: researchfish
- Medical Research Council [G0502183] Funding Source: researchfish
- Science and Technology Facilities Council [ST/K001957/1] Funding Source: researchfish
Background and purpose: Gold nanoparticles (GNPs) are novel agents that have been shown to cause radiosensitisation in vitro and in vivo. Tumour hypoxia is associated with radiation resistance and reduced survival in cancer patients. The interaction of GNPs with cells in hypoxia is explored. Materials and methods: GNP uptake, localization, toxicity and radiosensitisation were assessed in vitro under oxic and hypoxic conditions. Results: GNP cellular uptake was significantly lower under hypoxic than oxic conditions. A significant reduction in cell proliferation in hypoxic MDA-MB-231 breast cancer cells exposed to GNPs was observed. In these cells significant radiosensitisation occurred in normoxia and moderate hypoxia. However, in near anoxia no significant sensitisation occurred. Conclusions: GNP uptake occurred in hypoxic conditions, causing radiosensitisation in moderate, but not extreme hypoxia in a breast cancer cell line. These findings may be important for the development of GNPs for cancer therapy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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