期刊
RADIOTHERAPY AND ONCOLOGY
卷 111, 期 1, 页码 18-24出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2013.10.023
关键词
Radiotherapy; Bone metastases; Biomarker; Physical activity; Gait
资金
- Faculty of Medicine at the Norwegian University of Technology and Science in Trondheim, Norway
- Translational Medicine Research Collaboration
Background and purpose: An objective measure of pain relief may add important information to patients' self assessment, particularly after a treatment. The study aims were to determine whether measures of physical activity and/or gait can be used in characterizing cancer-induced bone pain (CIBP) and whether these biomarkers are sensitive to treatment response, in patients receiving radiotherapy (XRT) for CIBP. Materials and methods: Patients were assessed before (baseline) and 6-8 weeks after XRT (follow up). The following assessments were done: Brief Pain Inventory (BPI), activPAL (TM) activity meter, and GAITRite (R) electronic walkway (measure of gait). Wilcoxon, Mann Whitney and Pearson statistical analyses were done. Results: Sixty patients were assessed at baseline; median worst pain was 7 and walking interference was 5. At follow up 42 patients were assessed. BPI worst pain, average pain, walking interference and total functional interference all improved (p < 0.001). An improvement in functional interference correlated with aspects of physical activity (daily hours standing r = 0.469, p = 0.002) and gait (cadence r = 0.341, p = 0.03). The activPAL and GAITRite parameters did not change following XRT (p > 0.05). In responder analyses there were no differences in activPAL and GAITRite parameters (p > 0.05). Conclusion: Assessment of physical activity and gait allow a characterization of the functional aspects of CIBP, but not in the evaluation of XRT. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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