期刊
RADIOTHERAPY AND ONCOLOGY
卷 108, 期 2, 页码 306-313出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2013.05.038
关键词
Quality of life; Radical prostatectomy; External beam radiotherapy; Prostate brachytherapy; EPIC
资金
- Instituto de Salud Carlos III FEDER [ETE-PI08/90090]
- FIS [PI020668]
- DURSI-GENCAT [2005-SGR-00491, 2009 SGR 1095]
- AATRM [086/24/2000, 436/05/2008]
- National Health System, Instituto Nacional Carlos III [CA06/0081]
Purpose: To assess long-term quality of life (QoL) impact of treatments in localized prostate cancer patients treated with radical prostatectomy, external beam radiotherapy or brachytherapy. Material and methods: Observational, prospective cohort study with pre-treatment QoL evaluation and follow-up until five years after treatment. 704 patients with low or intermediate risk localized prostate cancer were consecutively recruited in 2003-2005. QoL was measured by the EPIC questionnaire, with urinary irritative-obstructive, incontinence, bowel, sexual, and hormonal scores (ranging 0-100). Results: Brachytherapy's QoL impact was restricted to the urinary domain, Generalized Estimating Equation models showed score changes at five years of -12.0 (95% CI = -15.0, -9.0) in incontinence and -5.3 (95% Cl = -7.5, -3.1) in irritative-obstructive scales. Compared to brachytherapy, radical prostatectomy fared +3.3 (95% Cl = +0.0, +6.5) points better in irritative-obstructive but -17.1 (95% CI = -22.7, -11.5) worse in incontinence. Sexual deterioration was observed in radical prostatectomy (-19.1; 95% CI = -25.1, -13.1) and external radiotherapy groups (-7.5; 95% CI = -12.5, -2.5). Conclusions: Brachytherapy is the treatment causing the least impact on QoL except for moderate urinary irritative-obstructive symptoms. Our study provides novel long-term valuable information for clinical decision making, supporting brachytherapy as a possible alternative to radical prostatectomy for patients seeking an attempted curative treatment, while limiting the risk for urinary incontinence and sexual impact on QoL. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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