期刊
FOOD & FUNCTION
卷 6, 期 8, 页码 2779-2786出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5fo00626k
关键词
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资金
- National Natural Science Foundation of China [31071531]
- Scientific Research Fund of the Hunan Provincial Education Department [14A071]
Obesity, considered as a consequence of overnutrition, sustains a low-degree inflammatory state and results in insulin-resistance and type 2 diabetes. Here, we investigated the anti-inflammatory effects of 5-caffeoylquinic acid (5-CQA) in high-fat diet-induced obese rats. Serum interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), total cholesterol (TC), triglyceride (TG), and free fatty acid (FFA) levels were determined. Expression of genes related to TG metabolism, macrophage biomarkers, and inflammation was assessed by real-time PCR. Protein expression of NF-kappa B, PPAR gamma 2, and phosphorylated I kappa B alpha was evaluated by western blotting, and the histology of adipose tissue was examined. Supplementation of the rat diet with 5-CQA reduced obesity development, macrophage infiltration, and steatosis. Additionally, 5-CQA decreased the expression of NF-kappa B and downstream inflammatory cytokines, but increased the expression of PPAR gamma 2, in a dose-dependent manner. Thus, 5-CQA improved obesity and obesity-related metabolic disturbances via PPAR gamma 2 and the NF-kappa B signaling pathway.
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