期刊
EUROINTERVENTION
卷 11, 期 3, 页码 319-324出版社
EUROPA EDITION
DOI: 10.4244/EIJV11I3A59
关键词
acute coronary syndrome; optical coherence tomography; plaque erosion; plaque rupture
Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth neointima, while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.
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