期刊
RADIOLOGIA MEDICA
卷 115, 期 8, 页码 1314-1329出版社
SPRINGER
DOI: 10.1007/s11547-010-0575-3
关键词
Prostate cancer; Biopsy; Magnetic resonance; Spectroscopy
Purpose. The purpose of this study was to evaluate the role of magnetic resonance spectroscopic imaging (MRSI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in detecting tumour foci in patients with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (TRUS)-guided biopsy. Materials and methods. This prospective randomised trial was conducted on 150 patients who underwent [H-1]MRSI and DCE-MRI and targeted biopsies of suspicious areas on MRI associated with random biopsies. Results. After the second biopsy, the diagnosis of prostate adenocarcinoma was made in 64/150 cases. On a per-patient basis, MRSI had 82.8% sensitivity, 91.8% specificity, 88.3% positive predictive value (PPV), 87.8% negative predictive value (NPV) and 85.7% diagnostic accuracy. The sensitivity, specificity, PPV, NPV and accuracy for DCE-MRI was 76.5%, 89.5%, 84.5%, 83.7% and 82%, respectively. The combination of MRSI and DCE-MRI yielded 93.7% sensitivity, 90.7% specificity, 88.2% PPV, 95.1% NPV and 90.9% accuracy in detecting prostate carcinoma. Conclusions. The combined study with [H-1]MRSI and DCE-MRI showed promising results in guiding the biopsy of cancer foci in patients with an initial negative TRUS-guided biopsy.
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