期刊
CURRENT PSYCHIATRY REPORTS
卷 17, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-015-0637-2
关键词
Circadian rhythm; Psychiatric disorders; Metabolic syndrome; Depression; Reward; Obesity
类别
资金
- Veterans Affairs Merit Award [1I01BX001146]
- NARSAD
Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
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