期刊
QUARTERLY REVIEWS OF BIOPHYSICS
卷 45, 期 3, 页码 257-299出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033583512000054
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资金
- Keck Center for Interdisciplinary Bioscience Training of the Gulf Coast Consortia [5T15LM07093]
- Robert A. Welch Foundation [E-1028]
- National Institutes of Health [(R01 GM066813]
- NIH [R01 AI054830]
- UK Engineering and Physics Science Research Council
The predominant protein-centric perspective in protein-DNA-binding studies assumes that the protein drives the interaction. Research focuses on protein structural motifs, electrostatic surfaces and contact potentials, while DNA is often ignored as a passive polymer to be manipulated. Recent studies of DNA topology, the supercoiling, knotting, and linking of the helices, have shown that DNA has the capability to be an active participant in its transactions. DNA topology-induced structural and geometric changes can drive, or at least strongly influence, the interactions between protein and DNA. Deformations of the B-form structure arise from both the considerable elastic energy arising from supercoiling and from the electrostatic energy. Here, we discuss how these energies are harnessed for topology-driven, sequence-specific deformations that can allow DNA to direct its own metabolism.
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