期刊
CELL ADHESION & MIGRATION
卷 9, 期 1-2, 页码 141-153出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2014.1000074
关键词
cancer; extracellular matrix; tenascin-C; tumor microenvironment
类别
资金
- Arthritis Research UK [20003] Funding Source: Medline
- Versus Arthritis [20003] Funding Source: Medline
Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure and still causes far too high a death rate. Based on advances in our understanding of disease pathogenesis, novel treatment concepts, including targeting the tumor microenvironment, have been developed and are being combined with established treatment regimens such as surgical removal and radiotherapy. Yet it is obvious that we need additional strategies to prevent tumor relapse and metastasis. Given its exceptional high expression in most cancers with low abundance in normal tissues, tenascin-C appears an ideal candidate for tumor treatment. Here, we will summarize the current applications of targeting tenascin-C as a treatment for different tumors, and highlight the potential of this therapeutic approach.
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