期刊
CELL ADHESION & MIGRATION
卷 9, 期 3, 页码 183-192出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1005466
关键词
adherens junction; -catenin; apico-basal polarity; N-cadherin; neural progenitor cells; AJ; adherens junction; aPKC; atypical protein kinase C; EC; extracellular; Fox; forkhead box; Frz; frizzled; GFAP; glial fibrillary acidic protein; GSK3; glycogen synthase kinase 3; Hes; hairly; enhancer of split; Hh; hedgehog; IP; intermediate progenitor; iPSC; induced pluripotent stem cell; KO; knockout; LEF; lymphocyte enhancer factor; ngn2; neurogenin 2; NPC; neural progenitor cell; Par; partition defective complex protein; Ptc; Pached; shRNA; short hairpin RNA; Smo; smoothened; Sox2; sry (sex determining region Y)-box containing gene 2; TCF; T-cell factor; TA cell; transient amplifying cell; ZO-1; Zonula Occludens-1
类别
This review addresses our current understanding of the regulatory mechanism by which N-cadherin, a classical cadherin, affects neural progenitor cells (NPCs) during development. N-cadherin is responsible for the integrity of adherens junctions (AJs), which develop in the sub-apical region of NPCs in the neural tube and brain cortex. The apical domain, which contains the sub-apical region, is involved in the switching from symmetric proliferative division to asymmetric neurogenic division of NPCs. In addition, N-cadherin-based AJ is deeply involved in the apico-basal polarity of NPCs and the regulation of Wnt--catenin, hedgehog (Hh), and Notch signaling. In this review, we discuss the roles of N-cadherin in the maintenance, proliferation, and differentiation of NPCs through components of AJ, -catenin and E-catenin.
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