期刊
CELL ADHESION & MIGRATION
卷 9, 期 5, 页码 406-415出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1005465
关键词
migration; small transmembrane proteins; therapeutics; tetraspanin
类别
资金
- National Natural Science Foundation of China [30973125]
- State Key Development Program for Basic Research of China (973 Program) [2012CB518101]
Tetraspanins are a superfamily of small transmembrane proteins that are expressed in almost all eukaryotic cells. Through interacting with one another and with other membrane and intracellular proteins, tetraspanins regulate a wide range of proteins such as integrins, cell surface receptors, and signaling molecules, and thereby engage in diverse cellular processes ranging from cell adhesion and migration to proliferation and differentiation. In particular, tetraspanins modulate the function of proteins involved in all determining factors of cell migration including cell-cell adhesion, cell-ECM adhesion, cytoskeletal protrusion/contraction, and proteolytic ECM remodeling. We herein provide a brief overview of collective in vitro and in vivo studies of tetraspanins to illustrate their regulatory functions in the migration and trafficking of cancer cells, vascular endothelial cells, skin cells (keratinocytes and fibroblasts), and leukocytes. We also discuss the involvement of tetraspanins in various pathologic and remedial processes that rely on cell migration and their potential value as targets for therapeutic intervention.
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