期刊
QUALITY OF LIFE RESEARCH
卷 20, 期 7, 页码 1111-1121出版社
SPRINGER
DOI: 10.1007/s11136-011-9846-2
关键词
Menopause; Profile of Mood States; Validity; Structural equation modeling
类别
资金
- Wyeth Research, Collegeville, Pennsylvania
- Pfizer Inc.
Purpose To evaluate the psychometric properties of the Profile of Mood States (POMS) in postmenopausal women with moderate to severe vasomotor symptoms. Methods Internal consistency, validity, and reliability of the POMS were examined using blinded data from 539 postmenopausal women with a parts per thousand yen50 moderate to severe hot flushes per week at baseline enrolled in a multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of desvenlafaxine (administered as desvenlafaxine succinate) for vasomotor symptoms. Results The POMS subscales and total score demonstrated sound internal consistency reliability (alpha a parts per thousand yen 0.84). Comparisons between POMS subscales and Total Mood Disturbance (TMD) scores with Greene Climacteric Scale domains provided consistent known-groups and construct validity. Results from the confirmatory factor analysis were supportive of the second-order factor structure (root-mean-square error of approximation = 0.078). For women with POMS TMD scores below the US adult female norms, there was little mean change at Week 12 but marked mean improvement in women with greater mood symptoms scoring worse than the norm at baseline. Conclusion These data demonstrate the internal consistency and validity of the POMS to measure mood among postmenopausal women with moderate to severe hot flushes and the responsiveness of the POMS among these women with greater mood symptoms.
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