期刊
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
卷 107, 期 4, 页码 253-259出版社
OXFORD UNIV PRESS
DOI: 10.1093/qjmed/hcu025
关键词
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资金
- MRC
- Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust
- Diabetes UK [13/0004678] Funding Source: researchfish
- Medical Research Council [MR/J015377/1] Funding Source: researchfish
- MRC [MR/J015377/1] Funding Source: UKRI
Cell therapy in the form of human islet transplantation has been a successful form of treatment for patients with type 1 diabetes for over 10 years, but is significantly limited by lack of suitable donor material. A replenishable supply of insulin-producing cells has the potential to address this problem; however to date success has been limited to a few preclinical studies. Two of the most promising strategies include differentiation of embryonic stem cells and induced pluripotent stem cells towards insulin-producing cells and transdifferentiation of acinar or other closely related cell types towards beta-cells. Here, we discuss recent progress and challenges that need to be overcome in taking cell therapy to the clinic.
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