期刊
PURINERGIC SIGNALLING
卷 6, 期 2, 页码 155-166出版社
SPRINGER
DOI: 10.1007/s11302-010-9189-4
关键词
Cochlea; Supporting cell; ATP; Calcium; Chloride channel; Crenation; Development
资金
- NIH [GM53395, DC008860, DC009464, NS050274]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM053395] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS050274, R01NS069720] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC008860, R21DC009464] Funding Source: NIH RePORTER
The developing cochlea of mammals contains a large group of columnar-shaped cells, which together form a structure known as Kolliker's organ. Prior to the onset of hearing, these inner supporting cells periodically release adenosine 5'-triphosphate (ATP), which activates purinergic receptors in surrounding supporting cells, inner hair cells and the dendrites of primary auditory neurons. Recent studies indicate that purinergic signaling between inner supporting cells and inner hair cells initiates bursts of action potentials in auditory nerve fibers before the onset of hearing. ATP also induces prominent effects in inner supporting cells, including an increase in membrane conductance, a rise in intracellular Ca2+, and dramatic changes in cell shape, although the importance of ATP signaling in non-sensory cells of the developing cochlea remains unknown. Here, we review current knowledge pertaining to purinergic signaling in supporting cells of Kolliker's organ and focus on the mechanisms by which ATP induces changes in their morphology. We show that these changes in cell shape are preceded by increases in cytoplasmic Ca2+, and provide new evidence indicating that elevation of intracellular Ca2+ and IP3 are sufficient to initiate shape changes. In addition, we discuss the possibility that these ATP-mediated morphological changes reflect crenation following the activation of Ca2+-activated Cl- channels, and speculate about the possible functions of these changes in cell morphology for maturation of the cochlea.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据