期刊
PURE AND APPLIED CHEMISTRY
卷 86, 期 9, 页码 1335-1355出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/pac-2014-0607
关键词
lectin folds; ligand specificity; ICS-27; molecular evolution; mycobacterial lectins; quaternary association
资金
- Department of Science and Technology
Structural studies in this laboratory encompass four of the five major classes of plant lectins, including the one discovered by us. In addition to addressing issues specific to individual lectins, the work provided insights into protein folding, quaternary association and generation of ligand specificity. Legume and beta-prism fold lectins constitute families of proteins in which small alterations in essentially the same tertiary structure lead to large variations in quaternary structure, including that involving an open structure. Strategies for generating ligand specificity include water bridges, variation in loop length, post translational modification and oligomerization. Three of the structural classes investigated have subunits with three-fold symmetry. The symmetry in the structure is reflected in the sequence to different extents in different subclasses. The evolutionary implications of this observation have been explored. The work on lectins has now been extended to those from mycobacteria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据