Catalytic synthesis of amines and N-containing heterocycles: Amidate complexes for selective C-N and C-C bond-forming reactions

The direct, 100 % atom-economic, and selective synthesis of amines is a challenging task that can be achieved, making use of early transition-metal catalysts. Here we report the synthesis and application of group 4 and 5 high-oxidation-state metal amidate complexes in catalytic C-N (hydroamination) and C-C (hydroaminoalkylation) bond-forming reactions to access substituted amines.