期刊
PURE AND APPLIED CHEMISTRY
卷 81, 期 2, 页码 227-234出版社
WALTER DE GRUYTER GMBH
DOI: 10.1351/PAC-CON-08-08-19
关键词
amino acids; catalysis; copper; coupling; synthesis
Ullmann-type coupling reactions between aryl halides and N-containing reagents, phenols, and other related nucleophilic agents are very valuable transformations for organic synthesis. Their conventional reaction conditions require high reaction temperatures. We describe here that some amino acids, either as substrates or ligands, can lead Cu-catalyzed C-N, C-O, C-S, and C-C bond formations work at relatively low temperatures. An ortho-substitution effect caused by NHCOR groups is discussed. Applications of these newly developed reactions to heterocycle preparation and asymmetric synthesis are also presented.
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