期刊
PULMONARY PHARMACOLOGY & THERAPEUTICS
卷 26, 期 1, 页码 75-85出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2012.07.002
关键词
Airway smooth muscle; Asthma; Epigenetics; Inflammation; microRNA; Remodeling
资金
- Wellcome Trust
- National Institutes of Health [HL080960]
- National Center for Research Resources [RR016464]
- National Institute of General Medical Sciences [GM103440]
- Medical Research Council
Regulation of phenotypic plasticity in smooth muscle requires an understanding of the mechanisms regulating phenotype-specific genes and the processes dysregulated during pathogenesis. Decades of study in airway smooth muscle has provided extensive knowledge of the gene expression patterns and signaling pathways necessary to maintain and alter smooth muscle cell phenotype. With this solid foundation, the importance and complexity of inheritable epigenetic modifications and mechanisms silencing gene expression have now emerged as fundamental components regulating aspects of inflammation, proliferation and remodeling. (C) 2012 Elsevier Ltd. All rights reserved.
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