期刊
PULMONARY PHARMACOLOGY & THERAPEUTICS
卷 22, 期 5, 页码 388-397出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2008.09.006
关键词
Calcium; K+ channels; Proliferation; Secretion; Contraction; Oscillations; Ca2+
资金
- NHLBI NIH HHS [HL71930, R01 HL071930-05, R33 HL087401, HL 087401, R33 HL087401-02, R01 HL071930] Funding Source: Medline
Airway hyper-responsiveness associated with asthma is mediated by airway smooth muscle cells (SMCs) and has a complicated etiology involving increases in cell contraction and proliferation and the secretion of inflammatory mediators. Although these pathological changes are diverse, a common feature associated with their regulation is a change in intracellular Ca2+ concentration ([Ca2+](i)). Because the [Ca2+](i), itself is a function of the activity and expression of a variety of ion channels, in both the plasma membrane and sarcoplasmic reticulum of the SMC, the modification of this ion channel activity may predispose airway SMCs to hyper-responsiveness. Our objective is to review how ion channels determine the [Ca2+](i), and influence the function of airway SMCs and emphasize the potential of ion channels as sites for therapeutic approaches to asthma. (C) 2008 Elsevier Ltd. All rights reserved.
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