期刊
PUBLIC HEALTH NUTRITION
卷 17, 期 8, 页码 1825-1833出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1368980013002565
关键词
Diet; Inflammation; C-reactive protein; Adults; Predictive ability
资金
- South Carolina Statewide Cancer Prevention and Control Program Research Fund
- National Heart, Lung, and Blood Institute [1R01 HL073194, 1R01HL094575-01A1]
- Cancer Training Branch of the National Cancer Institute [K05 CA136975]
Objective: To perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator. Design: Using data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i. e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (<= 3mg/l, >3mg/l), while controlling for important potential confounders. Setting: Existing data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year. Subjects: Participants who had at least one hs-CRP measurement over her/his 1-year participation (n 495 for 24HR, n 559 for 7DDR). Results: Higher DII scores were associated with values of hs-CRP >3mg/l (OR = 1.08; 95% CI 1.01, 1.16, P = 0.035 for the 24HR; and OR = 1.10; 95% CI 1.02, 1.19, P = 0.015 for the 7DDR). Conclusions: The population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals' intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.
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