Psychotropic-Induced Hyperprolactinemia: A Clinical Review

Background: Psychotropic medications, particularly select antipsychotics, are a common cause of drug-induced hyperprolactinemia. As high prolactin may be associated with hypogonadism, reproductive dysfunction, and bone loss, it is important to recognize this condition and understand its management. Objective: The aim of this review is to evaluate the causes, signs, and symptoms associated with hyperprolactinemia, to describe mechanisms through which psychotropic medications elevate prolactin, and to suggest an evidence-based management approach for patients with psychotropic drug-induced hyperprolactinemia. Methods: A PubMed/MEDLINE search was conducted on the topic of psychotropic agents' as a cause of hyperprolactinemia. The material with most relevance to current psychiatric practice and of highest level of