期刊
PSYCHOSOMATIC MEDICINE
卷 72, 期 8, 页码 748-754出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PSY.0b013e3181eff148
关键词
depression; omega-3; heart rate variability
资金
- National Heart, Lung, and Blood Institute [RO1 HL076808]
- Lewis and Jean Sachs Charitable Lead Trust
Objective: To determine whether omega-3 fatty acid (FA) increases the natural log of very low frequency (InVLF) power, an index of heart rate variability (HRV), and reduces 24-hour heart rate (HR) in depressed patients with coronary heart disease (CHD). Low intake of omega-3 FAs is associated with depression and with low HRV, and all three are associated with an increased risk of death in patients with CHD. Methods: Thirty-six depressed patients with CHD randomized to receive 50 mg of sertraline and 2 g of omega-3/day, and 36 randomized to sertraline and a placebo, had 24-hour HRV measured at baseline and after 10 weeks of treatment. Results: There was a significant treatment x time interaction for covariate adjusted InVLF (p =.009), for mean 24-hour HR (p = .03), and for 1-minute resting HR (p = .02). The interaction was not significant for three other measures of H RV. LnVLF did not change over time in the omega-3 arm but decreased in the placebo arm (p = .002), suggesting that omega-3 may have prevented or slowed deterioration in cardiac autonomic function. Conclusions: The effects of omega-3 FAs on InVLF and HR, although modest, were detected after only 10 weeks of treatment with 2 g per day of omega-3. Whether a longer course of treatment or a higher dose of omega-3 would further decrease HR, improve other indices of HRV, or reduce mortality in depressed CHD patients should be investigated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据