期刊
BLOOD CANCER JOURNAL
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bcj.2015.56
关键词
-
资金
- National Institutes of Health [P50 CA97274]
- Leukemia & Lymphoma Society
- Predolin Foundation
- Scientific Research Funds for Young Scholars from Shanghai Municipal Public Health Bureau [20124Y124]
The biological role of monocytes and macrophages in B-cell non-Hodgkin lymphoma (NHL) is not fully understood. We have previously reported that monocytes from patients with B-cell NHL have an immunosuppressive CD14(+)HLA-DRlow/- phenotype that correlates with a poor prognosis. However, the underlying mechanism by which CD14(+)HLA-DRlow/- monocytes develop in lymphoma is unknown. In the present study, we found that interleukin (IL)-10, which is increased in the serum of patients with B-cell NHL, induced the development of the CD4(+)HLA-DRlow/- population. Using peripheral blood samples from patients with B-cell NHL, we found that absolute numbers of CD14(+)monocytic cells with an HLA-DRlow/- phenotype were higher than healthy controls and correlated with a higher International Prognostic Index score. IL-10 serum levels were elevated in lymphoma patients compared with controls and were associated with increased peripheral monocyte counts. Treatment of monocytes with IL-10 in vitro significantly decreased HLA-DR expression and resulted in the expansion of CD14(+)HLA-DRlow/- population. We found that lymphoma B cells produce IL-10 and supernatants from cultured lymphoma cells increased the CD14(+)HLA-DRlow/- population. Furthermore, we found that IL-10-induced CD14(+)HLA-DRlow/- monocytes inhibited the activation and proliferation of T cells. Taken together, these results suggest that elevated IL-10 serum levels contribute to increased numbers of immunosuppressive CD14(+) HLA-DRlow(/-) monocytes in B-cell NHL.
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