期刊
PSYCHOPHYSIOLOGY
卷 49, 期 9, 页码 1200-1214出版社
WILEY
DOI: 10.1111/j.1469-8986.2012.01443.x
关键词
Motivation; Normal volunteers; fMRI; PET; MRI
资金
- National Institute of Mental Health [R01 MH61358, P50 MH079485, T32 MH19554]
- National Institute of Drug Abuse [R21 DA14111]
- Beckman Institute for Advanced Science and Technology of the University of Illinois at Urbana-Champaign
Research indicates that dorsolateral prefrontal cortex (DLPFC) is important for pursuing goals, and areas of DLPFC are differentially involved in approach and avoidance motivation. Given the complexity of the processes involved in goal pursuit, DLPFC is likely part of a network that includes orbitofrontal cortex (OFC), cingulate, amygdala, and basal ganglia. This hypothesis was tested with regard to one component of goal pursuit, the maintenance of goals in the face of distraction. Examination of connectivity with motivation-related areas of DLPFC supported the network hypothesis. Differential patterns of connectivity suggest a distinct role for DLPFC areas, with one involved in selecting approach goals, one in selecting avoidance goals, and one in selecting goal pursuit strategies. Finally, differences in trait motivation moderated connectivity between DLPFC and OFC, suggesting that this connectivity is important for instantiating motivation.
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