期刊
BIOMEDICAL OPTICS EXPRESS
卷 6, 期 3, 页码 918-932出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.000918
关键词
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资金
- National Institutes of Health grant [R01 CA157277, P41-EB002182]
- National Institutes of Health grant (NIH Director's Pioneer Award) [DP1 EB016986]
- National Institutes of Health grant (NIH Director's Transformative Research Award) [R01 CA186567]
- Microphotoacoustics, Inc.
- Endra, Inc.
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents. (C) 2015 Optical Society of America
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