4.6 Article

Observation of sound-induced corneal vibrational modes by optical coherence tomography

期刊

BIOMEDICAL OPTICS EXPRESS
卷 6, 期 9, 页码 3313-3319

出版社

OPTICAL SOC AMER
DOI: 10.1364/BOE.6.003313

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资金

  1. National Institutes of Health [R01-EY025454, P41-EB015903, UL1-RR025758, R21EY023043, K25EB015885]
  2. National Science Foundation [1264356]
  3. European Research Council [ERC-2011 AdG-294099]
  4. Spanish Government [FIS2011-25637, FIS2014-56643-R, FPI-BES-2009-024560]
  5. Div Of Chem, Bioeng, Env, & Transp Sys
  6. Directorate For Engineering [1264356] Funding Source: National Science Foundation

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The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was similar to 8 mu m at a sound pressure level of 100 dB (2 Pa). Vibrography allows the visualization of the radially symmetric profiles of the resonance modes. A dynamic finite-element analysis supports our observation. (C)c 2015 Optical Society of America

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