期刊
BIOMEDICAL OPTICS EXPRESS
卷 6, 期 8, 页码 2997-3013出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.002997
关键词
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资金
- NSF CAREER [0954796]
- DoD MURI [W911NF-12-1-0594]
- NIH (NINDS) [R21NS053684, RO1NS076628, R01NS063226]
- Human Frontier Science Program
- Wallace H. Coulter Foundation
- Rodriguez Family
- NSF graduate fellowship
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS053684, R01NS076628, R01NS063226] Funding Source: NIH RePORTER
- Directorate For Engineering [0954796] Funding Source: National Science Foundation
We present an easily implemented wavefront correction scheme that has been specifically designed for in-vivo brain imaging. The system can be implemented with a single liquid crystal spatial light modulator (LCSLM), which makes it compatible with existing patterned illumination setups, and provides measurable signal improvements even after a few seconds of optimization. The optimization scheme is signal-based and does not require exogenous guide-stars, repeated image acquisition or beam constraint. The unconstrained beam approach allows the use of Zernike functions for aberration correction and Hadamard functions for scattering correction. Low order corrections performed in mouse brain were found to be valid up to hundreds of microns away from the correction location. (C) 2015 Optical Society of America
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