期刊
PSYCHOPHARMACOLOGY
卷 199, 期 1, 页码 109-117出版社
SPRINGER
DOI: 10.1007/s00213-008-1136-5
关键词
orexin; hypocretin; operant self administration; reinstatement; yohimbine; SB334867; stress; ethanol
Rationale Previous studies have shown that orexin-1/hypocretin1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Materials and methods Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 ( 0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 ( 0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine ( 0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 ( 0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. Results The orexin-1 receptor antagonist, SB334867 ( 10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 ( 5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. Conclusions The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据