期刊
PSYCHONEUROENDOCRINOLOGY
卷 38, 期 9, 页码 1835-1842出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2013.03.010
关键词
Telomere length; Telomerase; Stress; Lifespan; Prenatal; Fetal/developmental programming; Childhood stress; Mental health; Depression; Lifestyle
资金
- NICHD [HD061298]
- Jacobs Foundation
- US PHS (NIH) [HD-065825, HD-060628]
- NIA [BSR R01 AG030424, K99 HL109247]
- NIMH [R01 MH083784]
In the past decade, the growing field of telomere science has opened exciting new avenues for understanding the cellular and molecular substrates of stress and stress-related aging processes over the lifespan. Shorter telonnere length is associated with advancing chronological age and also increased disease morbidity and mortality. Emerging studies suggest that stress accelerates the erosion of telomeres from very early in life and possibly even influences the initial (newborn) setting of telomere length. In this review, we highlight recent empirical evidence linking stress and mental illnesses at various times across the lifespan with telomere erosion. We first present findings in the developmental programming of telomere biology linking prenatal stress to newborn and adult telomere length. We then present findings linking exposure to childhood trauma and to certain mental disorders with telomere shortening. Last, we review studies that characterize the relationship between related health-risk behaviors with telomere shortening over the lifespan, and how this process may further buffer the negative effects of stress on telomeres. A better understanding of the mechanisms that govern and regulate telomere biology throughout the lifespan may inform our understanding of etiology and the long-term consequences of stress and mental illnesses on aging processes in diverse populations and settings. (C) 2013 Elsevier Ltd. All rights reserved.
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