期刊
PSYCHONEUROENDOCRINOLOGY
卷 37, 期 9, 页码 1582-1586出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2012.02.014
关键词
Intranasal oxytocin; Salivary oxytocin; ELISA; Neuropeptide; Administration paradigms
资金
- Prof. Feldman's lab
- Israel Science Foundation [1318/08]
- US-Israel Bi-National Science Foundation [2005-273]
- NARSAD foundation
- Katz Family Foundation
- Kor Family Foundation
- Irving B. Harris Foundation
Following the discovery that intranasal administration of neuropeptides can reach the central nervous system, a growing number of studies applied intranasal oxytocin (OT) paradigms to demonstrate the positive effects of OT on social and emotional processes. The three-step paradigm typically included: OT administration, a 45-min waiting period, and approximately 1-h period of active drug effects when experimental manipulations are applied. Yet, this schedule has not been put to systematic validation. Utilizing a double-blind placebo-control within-subject design, ten individuals were administered OT or placebo and salivary OT was measured ten times, at baseline and nine times over four consecutive hours. OT administration induced substantial increases in salivary OT across the entire period. OT rose dramatically 15 min after administration (from 6.9 pg/ml at baseline to 1265.4 pg/ml), reached plateau at 45-120 min (range = 131.6 and 105.3 pg/ml), and did not return to baseline by 4 h. Results contribute to discussion on brain-periphery coordination of OT and highlight the need for further research on the temporal dynamics and durations of OT administration effects. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据