期刊
PSYCHONEUROENDOCRINOLOGY
卷 37, 期 2, 页码 270-279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2011.06.011
关键词
Pregnancy; Cortisol; Stress; Psychological distress; Anxiety; Depression; Ecological momentary assessment; Saliva; Diurnal
资金
- Alberta - Innovates health solutions
- Alberta Children's Hospital Research Institute for Child and Maternal Health
- Alberta Innovates
The mechanisms whereby maternal stress during pregnancy exerts organizational effects on fetal development require elaboration. The aim of this study was to assess the plausibility of cortisol as a biological link between maternal psychological distress during pregnancy and fetal development. Previous research has resulted in equivocal findings for between-persons differences in stress and cortisol. Ecological momentary assessment was used to simultaneously assess mood and cortisol 5 times daily for 3 days in 83 women (gestational ages 6-37 weeks). Results from multilevel analysis indicated a robust within-person association between negative mood and cortisol. For each 1.0% increase in negative mood there was a corresponding 1.9% increase in cortisol. This association was unaffected by advancing gestational age. The results suggest that cortisol is a plausible biological mechanism for transducing the effects of maternal psychological distress during pregnancy to fetal development. (C) 2011 Elsevier Ltd. All rights reserved.
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