期刊
BIOMEDICAL OPTICS EXPRESS
卷 6, 期 7, 页码 2522-2535出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.002522
关键词
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资金
- ERC Starting Grant [281356]
- European Research Council (ERC) [281356] Funding Source: European Research Council (ERC)
A pump-probe technique for the detection of fluorophores in tomographic PA images is introduced. It is based on inducing stimulated emission in fluorescent molecules, which in turn modulates the amount of thermalized energy, and hence the PA signal amplitude. A theoretical model of the PA signal generation in fluorophores is presented and experimentally validated on cuvette measurements made in solutions of Rhodamine 6G, a fluorophore of known optical and molecular properties. The application of this technique to deep tissue tomographic PA imaging is demonstrated by determining the spatial distribution of a near-infrared fluorophore in a tissue phantom. (C) 2015 Optical Society of America
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