期刊
PSYCHONEUROENDOCRINOLOGY
卷 34, 期 1, 页码 87-98出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2008.08.011
关键词
Meditation; Compassion; Mindfulness; Trier social stress test; Cortisol; Interleukin-6
资金
- National Institute of Mental Health [K23 MH064619]
- Emory College Seed Fund
- Emory Strategic Initiative funding
- PHS [UL1 RR025008, M01 RR0039]
- Clinical and Translational Science Award program
- General Clinical Research Center program
- National Institutes of Health
- National Center for Research Resources
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000039, UL1RR025008] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K23MH064619] Funding Source: NIH RePORTER
Meditation practices may impact physiological pathways that are modulated by stress and relevant to disease. While much attention has been paid to meditation practices that emphasize calming the mind, improving focused attention, or developing mindfulness, less is known about meditation practices that foster compassion. Accordingly, the current study examined the effect of compassion meditation on innate immune, neuroendocrine and behavioral responses to psychosocial stress and evaluated the degree to which engagement in meditation practice influenced stress reactivity. Sixty-one healthy adults were randomized to 6 weeks of training in compassion meditation (n = 33) or participation in a health discussion control group (n = 28) followed by exposure to a standardized laboratory stressor (Trier social stress test [TSST]). Physiologic and behavioral responses to the TSST were determined by repeated assessments of plasma concentrations of interteukin (IL)-6 and cortisol as well as total distress scores on the Profile of Mood States (POMS). No main effect of group assignment on TSST responses was found for IL-6, cortisol or POMS scores. However, within the meditation group, increased meditation practice was correlated with decreased TSST-induced IL-6 (r(p) = -0.46, p = 0.008) and POMS distress scores (r(p) = -0.43, p = 0.014). Moreover, individuals with meditation practice times above the median exhibited tower TSST-induced IL-6 and POMS distress scores compared to individuals below the median, who did not differ from controls. These data suggest that engagement in compassion meditation may reduce stress-induced immune and behavioral responses, although future studies are required to determine whether individuals who engage in compassion meditation techniques are more Likely to exhibit reduced stress reactivity. (C) 2008 Elsevier Ltd. All rights reserved.
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