期刊
PSYCHONEUROENDOCRINOLOGY
卷 33, 期 1, 页码 18-29出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2007.10.008
关键词
inflammation; depression; fatigue; proinflammatory; cytokines; brain; acute phase protein; symptom burden; biologic marker; therapy; animal models; neuroimaging
资金
- NCATS NIH HHS [UL1 TR000454] Funding Source: Medline
- NCI NIH HHS [R01 CA119159-04, R01 CA119159] Funding Source: Medline
- NCRR NIH HHS [M01 RR000865-358141, M01 RR000865] Funding Source: Medline
- NHLBI NIH HHS [R01 HL073921-04, R01 HL079955, R01 HL079955-04, R01 HL073921] Funding Source: Medline
- NIA NIH HHS [P30 AG028748, R01 AG029573, R01 AG029573-01, P30 AG028748-049004, R01 AG026364-05, R01 AG026364] Funding Source: Medline
- NIMH NIH HHS [R01 MH071349, K05 MH069124-05, K05 MH069124, R01 MH071349-04, T32 MH019925, T32 MH019925-10, T32 MH020018-09, R01 MH067990, P50 MH058922-090009, R01 MH071349-03, R01 MH071349-01, T32 MH020018, R01 MH079829-02, R01 MH075102-02, P50 MH058922, R01 MH079829, R01 MH071349-02, R01 MH075102, U19 MH069056, R01 MH079829-01, T32 MH019925-12, R01 MH067990-05, U19 MH069056-050003] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA119159] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000865] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL073921, R01HL079955] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH067990, R01MH075102, R01MH079829, T32MH019925, K05MH069124, U19MH069056, R01MH071349, P50MH058922, T32MH020018] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG029573, P30AG028748, R01AG026364] Funding Source: NIH RePORTER
Medically ill patients present with a high prevalence of non-specific comorbid symptoms including pain, sleep disorders, fatigue and cognitive and mood alterations that is a leading cause of disability. However, despite major advances in the understanding of the immune-to-brain communication pathways that underlie the pathophysiology of these symptoms in inflammatory conditions, little has been done to translate this newly acquired knowledge to the clinics and to identify appropriate therapies. In a multidisciplinary effort to address this problem, clinicians and basic scientists with expertise in areas of inflammation, psychiatry, neurosciences and psychoneuroimmunology were brought together in a specialized meeting organized in Bordeaux, France, on May 28-29, 2007. These experts considered key questions in the field, in particular those related to identification and quantification of the predominant symptoms associated with inflammation, definition of systemic and central markers of inflammation, possible domains of intervention for controlling inflammation-associated symptoms, and relevance of animal models of inflammation-associated symptoms. This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients. (C) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据