Effects of change in fatigue and depression on physical activity over time in relapsing-remitting multiple sclerosis

This prospective, observational study examined the effects of change in the symptoms of fatigue and depression on physical activity over time in persons with relapsing-remitting multiple sclerosis (RRMS). Adults with a confirmed diagnosis of RRMS completed a battery of questionnaires at baseline (n=269) and six-month follow-up (n=263). The data were analyzed using linear panel analysis and covariance modeling in Mplus 3.0. The panel model fit the data (2=24.00, df=15, p=0.07, SRMR=0.04, CFI=0.98) and demonstrated that changes in both fatigue (path coefficient=-0.09) and depressive symptoms (path coefficient=-0.12) were significantly associated with residual change in physical activity. Such findings support the importance of fatigue and depression for predicting longitudinal changes in physical activity in adults with RRMS.