期刊
PSYCHOLOGICAL MEDICINE
卷 43, 期 4, 页码 769-780出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001638
关键词
Cognitive function; fMRI; resting state; schizophrenia
资金
- National Nature Science Foundation of China [81130024, 30530300, 30125014]
- National Basic Research Program of China (973 Program) [2007CB512301]
- Ph.D. Programs Foundation of the Ministry of Education of China [20110181110014]
- National Key Technology R&D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan [2011BAZ02530]
- National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award
- Wellcome Trust
- China Postdoctoral Science Foundation [20090461337, 201003699]
- Medical Research Council [G9817803B] Funding Source: researchfish
Background. Given the important role of the default mode network (DMN) in cognitive function and the well-known neurocognitive deficit in schizophrenia, it is intriguing to examine systematically the relationship between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia. Method. First-episode, treatment-naive patients with schizophrenia (FES) (n=115) and healthy controls (n=113) underwent resting-state functional magnetic resonance imaging (fMRI) scans and neurocognitive tests. Intrinsic neural activities evaluated by using the fragment amplitude of low-frequency fluctuations (fALFF) and the resting-state functional connectivity assessed by seed-based correlational analysis were compared between patients and controls. Aberrant intrinsic activities and DMN connectivity in patients were then correlated to neurocognitive performance and clinical symptoms. Results. Compared to controls, patients with FES showed decreased fALFF in the bilateral medial prefrontal cortex (MPFC) and the orbitofrontal cortex (OFC), and increased fALFF in the bilateral putamen. Increased functional connectivity with the DMN was observed in the left insula and bilateral dorsolateral PFC (DLPFC) in patients with FES. In patients, aberrant fALFF in the bilateral OFC were correlated with cognitive processing speed; fALFF in the left OFC and right putamen were correlated with the clinical factors excited/activation and disorganization; and increased DMN functional connectivity in the left insula was correlated with the clinical factors positive, excited/activation, disorganization and neurocognitive deficit in the domain of sustained attention. Conclusions. These associations between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia may provide important insights into the neural mechanism of the disease.
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