4.7 Article

Cannabis affects people differently: inter-subject variation in the psychotogenic effects of Δ9-tetrahydrocannabinol: a functional magnetic resonance imaging study with healthy volunteers

期刊

PSYCHOLOGICAL MEDICINE
卷 43, 期 6, 页码 1255-1267

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001924

关键词

Cerebellum; fMRI; middle temporal gyri; parahippocampus; response inhibition; THC

资金

  1. Joint Medical Research Council/Priory clinical research training fellowship
  2. Psychiatry Research Trust, UK
  3. National Institutes of Health Research (NIHR) [NIHR-CS-011-001] Funding Source: National Institutes of Health Research (NIHR)
  4. Medical Research Council [G0501775] Funding Source: researchfish
  5. National Institute for Health Research [NIHR-CS-011-001] Funding Source: researchfish
  6. MRC [G0501775] Funding Source: UKRI

向作者/读者索取更多资源

Background. Cannabis can induce transient psychotic symptoms, but not all users experience these adverse effects. We compared the neural response to Delta(9)-tetrahydrocannabinol (THC) in healthy volunteers in whom the drug did or did not induce acute psychotic symptoms. Method. In a double-blind, placebo-controlled, pseudorandomized design, 21 healthy men with minimal experience of cannabis were given either 10 mg THC or placebo, orally. Behavioural and functional magnetic resonance imaging measures were then recorded whilst they performed a go/no-go task. Results. The sample was subdivided on the basis of the Positive and Negative Syndrome Scale positive score following administration of THC into transiently psychotic (TP; n=11) and non-psychotic (NP; n=10) groups. During the THC condition, TP subjects made more frequent inhibition errors than the NP group and showed differential activation relative to the NP group in the left parahippocampal gyrus, the left and right middle temporal gyri and in the right cerebellum. In these regions, THC had opposite effects on activation relative to placebo in the two groups. The TP group also showed less activation than the NP group in the right middle temporal gyrus and cerebellum, independent of the effects of THC. Conclusions. In this first demonstration of inter-subject variability in sensitivity to the psychotogenic effects of THC, we found that the presence of acute psychotic symptoms was associated with a differential effect of THC on activation in the ventral and medial temporal cortex and cerebellum, suggesting that these regions mediate the effects of the drug on psychotic symptoms.

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