期刊
PSYCHOLOGICAL MEDICINE
卷 43, 期 3, 页码 507-518出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001390
关键词
Depression; early life trauma; emotion regulation; graph theory; resting-state fMRI
资金
- National Institutes of Health [NIH P50 MN058922, NIH K01 MH073698]
- Agency for Healthcare Research and Quality (AHRQ)
- CeNeRx BioPharma
- PharmaNeuroBoost
Background. Early life stress (ELS) is a significant risk factor for depression. The effects of ELS exposure on neural network organization have not been differentiated from the effect of depression. Furthermore, many individuals exposed to ELS do not develop depression, yet the network organization patterns differentiating resiliency versus susceptibility to the depressogenic effects of ELS are not clear. Method. Women aged 18-44 years with either a history of ELS and no history of depression (n=7), a history of ELS and current or past depression (n=19), or a history of neither ELS nor depression (n=12) underwent a resting-state 3-T functional magnetic resonance imaging (fMRI) scan. An emotion regulation brain network consisting of 21 nodes was described using graph analyses and compared between groups. Results. Group differences in network topology involved decreased global connectivity and hub-like properties for the right ventrolateral prefrontal cortex (vlPFC) and decreased local network connectivity for the dorsal anterior cingulate cortex (dACC) among resilient individuals. Decreased local connectivity and increased hub-like properties of the left amygdala, decreased hub-like properties of the dACC and decreased local connectivity of the left vlPFC were observed among susceptible individuals. Regression analyses suggested that the severity of ELS (measured by self-report) correlated negatively with global connectivity and hub-like qualities for the left dorsolateral PFC (dlPFC). Conclusions. These preliminary results suggest functional neural connectivity patterns specific to ELS exposure and resiliency versus susceptibility to the depressogenic effects of ELS exposure.
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