期刊
PSYCHOLOGICAL MEDICINE
卷 42, 期 1, 页码 73-84出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291711001073
关键词
Default mode network; first-episode psychosis; functional imaging; schizophrenia
资金
- Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (CIBERSAM)
- Instituto de Salud Carlos III [CB07/09/0030 (CIBERSAM), CP07/00048 (RS), PI05/2693 (EP-C)]
Background. It is not known whether first-episode psychosis is characterized by the same prefrontal cortex functional imaging abnormalities as chronic schizophrenia. Method. Thirty patients with a first episode of non-affective functional psychosis and 28 healthy controls underwent functional magnetic resonance imaging (fMRI) during performance of the n-back working memory task. Voxel-based analyses of brain activations and deactivations were carried out and compared between groups. The connectivity of regions of significant difference between the patients and controls was also examined. Results. The first-episode patients did not show significant prefrontal hypo-or hyperactivation compared to controls. However, they showed failure of deactivation in the medial frontal cortex. This area showed high levels of connectivity with the posterior cingulate gyrus/precuneus and parts of the parietal cortex bilaterally. Failure of deactivation was significantly greater in first-episode patients who had or went on to acquire a DSM-IV diagnosis of schizophrenia than in those who did not, and in those who met RDC criteria for schizophrenia compared to those who did not. Conclusions. First-episode psychosis is not characterized by hypo-or hyperfrontality but instead by a failure of deactivation in the medial frontal cortex. The location and connectivity of this area suggest that it is part of the default mode network. The failure of deactivation seems to be particularly marked in first-episode patients who have, or progress to, schizophrenia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据