期刊
PSYCHOLOGICAL MEDICINE
卷 40, 期 11, 页码 1789-1795出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S003329171000005X
关键词
Efficacy; frontal cortex; major depressive disorder; transcranial magnetic stimulation; treatment
资金
- Netherlands Organization for Scientific Research (NWO) [VIDI 452-07-012]
Background. Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS to the frontal cortex in MDD. Method. A literature search was carried out in the databases PubMed and Web of Science in the period between January 1994 and July 2009 with the search terms 'depression' and 'transcranial magnetic stimulation'. Nine double-blind sham-controlled parallel intention-to-treat studies (252 patients) fulfilled inclusion criteria and were entered in a random-effects meta-analysis. Results. The test for heterogeneity was not significant (Q(T)=9.63, p=0.38). An overall weighted moderate mean effect size (d=0.63, 95% confidence interval=0.03-1.24) for active treatment was observed. Conclusions. The findings suggest that slow-frequency rTMS to the frontal cortex is more effective than sham treatment and may be equally effective as fast-frequency rTMS in the treatment of MDD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据