期刊
PSYCHOLOGICAL MEDICINE
卷 41, 期 5, 页码 1051-1060出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291710001601
关键词
Angry-hostility; deliberation; MAO-A; NEO-PI-R; personality; positron emission tomography; serotonin
资金
- Canadian Institutes of Health Research
- Ontario Mental Health Foundation
- Canadian Foundation for Innovation
- National Alliance for Research in Schizophrenia and Depression
- Eli-Lilly
- Lundbeck
- GlaxoSmithKline
- Bristol-Myers Squibb
Background. Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. In prefrontal cortex, low MAOA binding is associated with aggression and high binding is associated with major depressive disorder (MDD) and also risk for recurrence of depressive episodes. In rodent models, low MAOA levels are associated with increased aggression and fear conditioning, and decreased social and exploratory investigative behaviors. Our objective was to measure MAOA binding in prefrontal cortex and concurrently evaluate a broad range of validated personality traits. We hypothesized that prefrontal MAOA binding would correlate negatively with angry-hostility, a trait related to aggression/anger, and positively with traits intuitively related to adaptive investigative behavior. Method. Participants were aged 19-49 years, healthy and non-smoking. MAOA binding was measured with [C-11]harmine positron emission tomography (PET) in prefrontal brain regions and personality traits were measured with the NEO Personality Inventory Revised (NEO PI-R). Results. Prefrontal MAOA binding correlated negatively with angry-hostility (r = -0.515, p = 0.001) and positively with deliberation (r = 0.514, p = 0.001). In a two-factor regression model, these facets explained 38% of variance in prefrontal MAOA binding. A similar relationship was found in prefrontal cortex subregions. Conclusions. We propose a new continuum describing the relationship between personality and MAOA: deliberate/thoughtful contrasting aggressive/impulsive. Additionally, the association between high MAOA binding and greater deliberation may explain why some people have moderately high levels of MAOA, although very high levels occur during MDD. In health, higher MAOA binding is associated with an adaptive personality facet.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据