期刊
PSYCHOLOGICAL MEDICINE
卷 39, 期 3, 页码 393-402出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291708003620
关键词
Depression; executive function; neuropsychological; outcome; predictor
Background. Although cognitive variables have been shown to be useful in predicting outcomes in late-life depression, there has not yet been a comprehensive study in younger persons with depression. Method. The clinical symptoms and cognitive performance of participants were evaluated at admission to one of two university teaching hospitals and again at 3 months after remission and discharge. A total of 52 participants with a DSM-IV diagnosis of major depressive disorder, aged between 20 and 60 years and with a Hamilton Depression Rating Scale score >= 17 entered the study. The sample for this paper comprises the 48 subjects (mean age 37.9 years, S.D. = 10.7) who received admission and follow-up assessments; an attrition rate of 7.7%. Results. More perseverative errors on the shortened Wisconsin Card Sorting Test at admission predicted a worse clinical outcome at follow-up. Poor event-based prospective memory and more perseverative errors on the shortened Wisconsin Card Sorting Test at admission predicted worse social and occupational outcome at follow-up. Conclusions. These results suggest that a brief cognitive screen at hospital admission, focusing on executive function, would have a use prognostic value in depression. Determining early predictors of individuals at risk of poorer outcomes is important for identifying those who may need altered or additional treatment approaches.
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