期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 221, 期 3, 页码 210-219出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2013.12.004
关键词
Alcohol; Ventral striatum; Adolescence; Familial; Risk
资金
- Portland Alcohol Research Center [P60 AA010760, R01 MH096773, R00 MH091238]
- Oregon Clinical 82 Translational Research Institute
- [R01 AA017664]
- [U01 AA021691]
Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FRP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents. (C) 2013 Elsevier Ireland Ltd. All rights reserved,
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