期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 221, 期 1, 页码 6-12出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2013.10.002
关键词
Schizophrenia; Treatment response; Basal ganglia; Caudate; Risperidone; Magnetic resonance imaging (MRI)
资金
- National Institute of Mental Health [K01 MH081014]
- Howard Hughes Medical Institute's Medical to Graduate Initiative
- UAB Ireland Travel Scholarship
We investigated the relationship between basal ganglia volume and treatment response to the atypical antipsychotic medication risperidone in unmedicated patients with schizophrenia. Basal ganglia volumes included the bilateral caudate, putamen, and pallidum and were measured using the Freesurfer automated segmentation pipeline in 23 subjects. Also, baseline symptom severity, duration of illness, age, gender, time off medication, and exposure to previous antipsychotic were measured. Treatment response was significantly correlated with all three regions of the bilateral basal ganglia (caudate, pill:amen, and pallidum), baseline symptom severity, duration of illness, and age but not gender, time off antipsychotic medication, or exposure to previous antipsychotic medication. The caudate volume was the basal ganglia region that demonstrated the strongest correlation with treatment response and was significantly negatively correlated with patient age. Caudate volume was not significantly correlated with any other measure. We demonstrated a novel finding that the caudate volume explains a significant amount of the variance in treatment response over the course of 6 weeks of rispericlone pharmacotherapy even when controlling for baseline symptom severity and duration of illness. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据