期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 204, 期 2-3, 页码 168-177出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2012.09.005
关键词
Schizophrenia; Nicotine; Functional magnetic resonance imaging; Electroencephalography; Anterior cingulate cortex
资金
- Johnson & Johnson/Janssen Pharmaceutica
- Janssen Cilag
- Pfizer Inc.
- AstraZeneca
- Deutsche Forschungsgemeinschaft
- German Research Foundation (DFG, Deutsche Forschungsgemeinschaft) [SPP1226, Wi1316/7-1]
Nicotine can have beneficial effects on attention performance and corresponding brain function in both schizophrenia patients and healthy controls, but it remains controversial whether nicotine affects brain function differentially in patients vs. controls. The effects of nicotine on brain activity elicited by attention-requiring oddball-type tasks have not been studied in schizophrenia patients. In this study we sought to investigate the impact of nicotine on the p300 evoked potential component and corresponding fMRI (functional magnetic resonance imaging) activation measures in schizophrenia patients and controls. Applying a double-blind, placebo-controlled cross-over design, the effects of 1 mg nasal nicotine on brain activity elicited by a visual oddball-type task in N=14 schizophrenia and N=15 control smokers were studied with simultaneous EEG-fMRI. EEG single trial amplitudes were used to inform the fMRI analysis. We found a nicotine-associated increase in P300-informed fMRI activation in schizophrenia patients and controls, mainly in the anterior cingulate and adjacent medial frontal cortex. No group differences in the response to nicotine were found. Remarkably, averaged EEG and fMRI activation measures considered in isolation were largely unaffected by nicotine. Taken together, the effects of nicotine on P300 amplitude-associated brain activation do not seem to be fundamentally different in schizophrenic smokers and healthy controls. (C) 2012 Published by Elsevier Ireland Ltd.
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