期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 203, 期 1, 页码 67-74出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2011.08.013
关键词
Mild cognitive impairment (MCI); Alzheimer's disease (AD); Peripheral benzodiazepine receptor (PBR); Microglia; Positron emission tomography; [C-11]DAA1106
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Japanese Government
- MEXT [16591177]
- Grants-in-Aid for Scientific Research [23390235, 24591740, 16591177] Funding Source: KAKEN
Subjects with mild cognitive impairment (MCI) have prodromal or incipient dementia with neuropathological changes. Peripheral benzodiazepine receptor (PBR) binding was shown to reflect activated microglia, one of the predictive biomarkers of conversion to dementia. We sought to evaluate PBR binding in MCI subjects using positron emission tomography (PET). PET scans with [C-11]DAA1106, a potent and selective ligand for PBR. were performed on seven MCI subjects, 10 patients with Alzheimer's disease (AD) and 10 age-matched control subjects. PBR binding in the regions of interest was quantified by binding potential (BP). Five MCI subjects were clinically followed for 5 years after their initial PET scans. [C-11]DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls. We found no significant difference in BP between MCI and AD patients. MCI subjects with [C-11]DAA1106 binding values higher than the control mean + 0.5 standard deviation (S.D.) developed dementia within 5 years. Our finding of higher DAA binding in MCI subjects indicated that microglial activation may occur before the onset of dementia. In vivo detection of microglial activation may provide useful prognostic information with respect to stratifying MCI subjects at increased risk of dementia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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