期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 203, 期 2-3, 页码 175-179出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2012.02.007
关键词
Bipolar disorder; Resting state; fMRI; Amplitude of low-frequency fluctuation
资金
- 11th Five-Year Key Program for Science and Technology Development of China [2007BAI17B05]
- National Science Foundations of China (NSFC) [30900366]
- Program for Science and Technology of Beijing [D101107047810001]
- National Basic Research Program of China [2007CB512300]
- Capital Medical University Fundamental and Clinical Foundations of China [10JL63]
We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic resonance imaging (fMRI) signal. Unlike functional connectivity, the ALFF approach reflects local properties in specific regions and provides direct information about impaired foci. Groups of 26 patients with BD depression and 26 gender-, age-, and education-matched healthy subjects participated in fMRI scans. We examined group differences in ALFF findings as well as correlations between clinical measurements and ALFF in the regions showing significant group differences. Our results showed that patients with BD depression had significantly increased ALFF in the left insula, the right caudate nucleus, the temporal gyrus, the bilateral inferior frontal gyrus, and the posterior lobe of the cerebellum. They also had decreased ALFF in the left postcentral gyrus, the left parahippocampal gyrus, and the cerebellum. Moderate negative correlations were found between the Hamilton Depression Rating Scale score and ALFF in the left insular cortex in the patient group. These results support a model of BD that involves dysfunction in the prefrontal-limbic networks and associated striatal systems. We also demonstrated the feasibility of ALFF as a technique to investigate persistent cerebral dysfunction in BD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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