期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 204, 期 2-3, 页码 132-139出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2012.09.003
关键词
BDD; fMRI; Amygdala; Ventral visual stream; Limbic
资金
- National Institute of Mental Health [K23 MH079212-02]
- Obsessive Compulsive Foundation, Inc.
- UCLA Faculty Research Grant
Individuals with body dysmorphic disorder (BDD) often experience anxiety, as well as perceptual distortions of appearance. Anxiety has previously been found to impact visual processing. This study therefore tested the relationship between anxiety and visual processing of faces in BDD. Medication-free participants with BDD (N = 17) and healthy controls (N = 16) viewed photographs of their face and a familiar face during functional magnetic resonance imaging. Blood-oxygen-level dependent signal changes in regions involved in anxiety (amygdala) and detailed visual processing (ventral visual stream-VVS) were regressed on anxiety scores. Significant linear relationships between activity in the amygdala and VVS were found in both healthy controls and individuals with BDD. There was a trend of a quadratic relationship between anxiety and activity in the right VVS and a linear relationship between anxiety and activity in the left VVS for the BDD sample, and this was stronger for own-face stimuli versus familiar-face. Results suggest that anxiety symptoms in BDD may be associated with activity in systems responsible for detailed visual processing. This may have clinical implications related to heightened perceptual distortions associated with anxiety. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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