期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 192, 期 1, 页码 55-59出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2010.10.011
关键词
3T MRI; Proton magnetic resonance spectroscopy; Gamma-aminobutyric acid; Glutamate; Glutamine; Shift work
资金
- Grants-in-Aid for Scientific Research [23617035, 23590159] Funding Source: KAKEN
Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gin), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy (H-1-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm x 3.0 cm x 3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr and Glx/Cr), there were no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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